Modern scientists access an unprecedented level of knowledge on the basic components making up living systems; an ever-growing number of methods are currently available that allow parallel measurements of the behaviour and properties of all individual cellular components. Despite these spectacular progresses we still largely don’t understand how cellular components work collectively and achieve biological function. Understanding the molecular mechanisms of biological function largely relies on the systematic charting of the dynamics interactions taking place between the various components of living cells. Recent “OMICS” technologies contribute large biological networks covering entire proteomes. These networks are generally static as they fail to capture spatial and temporal dimensions that represent essential properties of living systems. Mechanistic and dynamic insights often come from focused smaller-scale approaches, such as those used in structural biology, biophysics or cell biology. The meeting will bring together leading scientists from the “OMICS” field with leading structural and cell biologists, for the main purpose of discussing scientific issues arising at the interface of these complementary fields. The general aim of the symposium is to explore the possible synergisms and cross-talk between the large-scale and classical approaches to biological networks and review/investigate possible avenue to more generally populate current networks with dynamics and mechanistic insights that will ensure high levels of biological understanding and contributes deciphering fundamental principles.
Signalling Networks and Circuits – Information networks
Multiscale analysis and integration of Cellular Networks
From Quantitative Network to Cell Biology – Cell Biology of Protein Networks
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